5xzg

<table><tr><td colspan='2'>[[5xzg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XZG FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEV:2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one'>AEV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase Cyclic GMP-AMP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.86 2.7.7.86] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xzg OCA], [http://pdbe.org/5xzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xzg RCSB], [http://www.ebi.ac.uk/pdbsum/5xzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xzg ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

 

 

== References ==

<references/>

[[Category: Cyclic GMP-AMP synthase]]

[[Category: Lk3 transgenic mice]]

[[Category: Adura, C]]

[[Category: Aida, J]]

[[Category: Asano, Y]]

[[Category: Ascano, M]]

[[Category: Aso, K]]

[[Category: Gao, P]]

[[Category: Glickman, J F]]

[[Category: Gogakos, T]]

[[Category: Imaeda, T]]

[[Category: Lama, L]]

[[Category: Luz, A]]

[[Category: Okamoto, R]]

[[Category: Patel, D J]]

[[Category: Reasoner, S]]

[[Category: Rothamel, K]]

[[Category: Steinberg, J]]

[[Category: Tuschl, T]]

[[Category: Vincent, J]]

[[Category: Sting]]