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1a8a

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[[Image:1a8a.gif|left|200px]]
 
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==RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE==
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The line below this paragraph, containing "STRUCTURE_1a8a", creates the "Structure Box" on the page.
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<StructureSection load='1a8a' size='340' side='right'caption='[[1a8a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A8A FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GSE:L-ALPHA-GLYCEROPHOSPHORYLSERINE'>GSE</scene></td></tr>
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{{STRUCTURE_1a8a| PDB=1a8a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a8a OCA], [https://pdbe.org/1a8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a8a RCSB], [https://www.ebi.ac.uk/pdbsum/1a8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a8a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ANXA5_RAT ANXA5_RAT] This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a8/1a8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a8a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
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'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE'''
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Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V.,Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670<ref>PMID:7583670</ref>
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==Overview==
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Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1A8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8A OCA].
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</div>
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<div class="pdbe-citations 1a8a" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583670 7583670]
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*[[Annexin 3D structures|Annexin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Concha NO]]
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[[Category: Concha, N O.]]
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[[Category: Dedman JR]]
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[[Category: Dedman, J R.]]
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[[Category: Kaetzel MA]]
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[[Category: Kaetzel, M A.]]
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[[Category: Seaton BA]]
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[[Category: Seaton, B A.]]
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[[Category: Swairjo MA]]
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[[Category: Swairjo, M A.]]
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[[Category: Calcium binding protein]]
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[[Category: Membrane binding protein]]
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[[Category: Phospholipid analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:57:44 2008''
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Current revision

RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOSERINE

PDB ID 1a8a

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