This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6aw5
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6aw5' size='340' side='right'caption='[[6aw5]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='6aw5' size='340' side='right'caption='[[6aw5]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6aw5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6aw5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw5 OCA], [https://pdbe.org/6aw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw5 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A452CSQ2_NANGA A0A452CSQ2_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] | ||
==See Also== | ==See Also== | ||
| Line 13: | Line 16: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Nannospalax galili]] |
| - | [[Category: Battaile | + | [[Category: Battaile KP]] |
| - | [[Category: Deng | + | [[Category: Deng Y]] |
| - | [[Category: Hanzlik | + | [[Category: Hanzlik RP]] |
| - | [[Category: Lovell | + | [[Category: Lovell S]] |
| - | [[Category: Mehzabeen | + | [[Category: Mehzabeen N]] |
| - | [[Category: Moskovitz | + | [[Category: Moskovitz J]] |
| - | [[Category: Shams | + | [[Category: Shams I]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
1.90A resolution structure of catechol O-methyltransferase (COMT) L136M (hexagonal form) from Nannospalax galili
| |||||||||||
