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6jgz

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Structure of RyR2 (F/P/Ca2+ dataset)

6jgz, resolution 4.60Å

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Retrieved from "http://52.214.119.220/wiki/index.php/6jgz"

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 ==Structure of RyR2 (F/P/Ca2+ dataset)==
-<StructureSection load='6jgz' size='340' side='right'caption='[[6jgz]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
+<SX load='6jgz' size='340' side='right' viewer='molstar' caption='[[6jgz]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6jgz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JGZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6jgz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JGZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JGZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jgz OCA], [https://pdbe.org/6jgz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jgz RCSB], [https://www.ebi.ac.uk/pdbsum/6jgz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jgz ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jgz OCA], [http://pdbe.org/6jgz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jgz RCSB], [http://www.ebi.ac.uk/pdbsum/6jgz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jgz ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/FKB1B_HUMAN FKB1B_HUMAN]] Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
+[https://www.uniprot.org/uniprot/FKB1B_HUMAN FKB1B_HUMAN] Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-The type 2 ryanodine receptor (RyR2) is responsible for releasing Ca(2+) from the sarcoplasmic reticulum of cardiomyocytes, subsequently leading to muscle contraction. Here, we report 4 cryo-electron microscopy (cryo-EM) structures of porcine RyR2 bound to distinct modulators that, together with our published structures, provide mechanistic insight into RyR2 regulation. Ca(2+) alone induces a contraction of the central domain that facilitates the dilation of the S6 bundle but is insufficient to open the pore. The small-molecule agonist PCB95 helps Ca(2+) to overcome the barrier for opening. FKBP12.6 induces a relaxation of the central domain that decouples it from the S6 bundle, stabilizing RyR2 in a closed state even in the presence of Ca(2+) and PCB95. Although the channel is open when PCB95 is replaced by caffeine and adenosine 5'-triphosphate (ATP), neither of the modulators alone can sufficiently counter the antagonistic effect to open the channel. Our study marks an important step toward mechanistic understanding of the sophisticated regulation of this key channel whose aberrant activity engenders life-threatening cardiac disorders.
-Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.,Chi X, Gong D, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N Proc Natl Acad Sci U S A. 2019 Dec 2. pii: 1914451116. doi:, 10.1073/pnas.1914451116. PMID:31792195<ref>PMID:31792195</ref>
+==See Also==
+*[[FKBP 3D structures|FKBP 3D structures]]
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]]
-</div>
-<div class="pdbe-citations 6jgz" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
-</StructureSection>
+</SX>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Peptidylprolyl isomerase]]
 [[Category: Sus scrofa]]
-[[Category: Chi, X M]]
+[[Category: Chi XM]]
-[[Category: Gong, D S]]
+[[Category: Gong DS]]
-[[Category: Huang, G X.Y]]
+[[Category: Huang GXY]]
-[[Category: Lei, J L]]
+[[Category: Lei JL]]
-[[Category: Ren, K]]
+[[Category: Ren K]]
-[[Category: Yan, N]]
+[[Category: Yan N]]
-[[Category: Zhou, G W]]
+[[Category: Zhou GW]]
-[[Category: Zhou, Q]]
+[[Category: Zhou Q]]
-[[Category: Cryo-em]]
-[[Category: Membrane protein]]

6jgz

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Structure of RyR2 (F/P/Ca2+ dataset)

Structural highlights

Function

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