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6r8i

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<StructureSection load='6r8i' size='340' side='right'caption='[[6r8i]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
<StructureSection load='6r8i' size='340' side='right'caption='[[6r8i]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6r8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R8I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6r8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R8I FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PPP4R3A, KIAA2010, PP4R3A, SMEK1, MSTP033 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.517&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8i OCA], [http://pdbe.org/6r8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r8i RCSB], [http://www.ebi.ac.uk/pdbsum/6r8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r8i OCA], [https://pdbe.org/6r8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r8i RCSB], [https://www.ebi.ac.uk/pdbsum/6r8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r8i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/P4R3A_HUMAN P4R3A_HUMAN]] Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.<ref>PMID:18614045</ref>
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[https://www.uniprot.org/uniprot/P4R3A_HUMAN P4R3A_HUMAN] Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.<ref>PMID:18614045</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6r8i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6r8i" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Protein phosphatase 3D structures|Protein phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cressey, L]]
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[[Category: Cressey L]]
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[[Category: Davey, N]]
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[[Category: Davey N]]
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[[Category: Garvanska, D H]]
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[[Category: Garvanska DH]]
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[[Category: Ivarsson, Y]]
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[[Category: Ivarsson Y]]
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[[Category: Jenkins, N P]]
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[[Category: Jenkins NP]]
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[[Category: Kettenbach, A]]
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[[Category: Kettenbach A]]
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[[Category: Kruse, T]]
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[[Category: Kruse T]]
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[[Category: Larsen, M S.Yoo]]
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[[Category: Lopez Mendez B]]
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[[Category: Mendez, B Lopez]]
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[[Category: Montoya G]]
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[[Category: Montoya, G]]
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[[Category: Nilsson J]]
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[[Category: Nilsson, J]]
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[[Category: Sundell GN]]
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[[Category: Sundell, G N]]
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[[Category: Ueki Y]]
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[[Category: Ueki, Y]]
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[[Category: Weisser MB]]
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[[Category: Weisser, M B]]
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[[Category: Yoo Larsen MS]]
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[[Category: Zhang, G]]
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[[Category: Zhang G]]
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[[Category: Evh1 domain]]
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[[Category: Peptide binding protein]]
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[[Category: Phosphatase]]
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[[Category: Pp4]]
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[[Category: Pp4c]]
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[[Category: Ppii polyproline helix]]
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[[Category: Ppp4r2]]
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[[Category: Ppp4r3a]]
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[[Category: Ppp4r3b]]
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Current revision

PP4R3A EVH1 domain bound to FxxP motif

PDB ID 6r8i

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