2c4t
From Proteopedia
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<StructureSection load='2c4t' size='340' side='right'caption='[[2c4t]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2c4t' size='340' side='right'caption='[[2c4t]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2c4t]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2c4t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C4T FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SA8:S-5-AZAMETHIONINE-5-DEOXYADENOSINE'>SA8</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c4t OCA], [https://pdbe.org/2c4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c4t RCSB], [https://www.ebi.ac.uk/pdbsum/2c4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c4t ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4t ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c4t ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Streptomyces cattleya kahan et al. 1979]] | ||
| - | [[Category: Adenosyl-fluoride synthase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Deng, H]] | ||
| - | [[Category: Hagan, D O]] | ||
| - | [[Category: McEwan, A R]] | ||
| - | [[Category: McGlinchey, R P]] | ||
| - | [[Category: Naismith, J H]] | ||
| - | [[Category: Robinson, D R]] | ||
| - | [[Category: 5'-fluorodeoxyadenosine synthase]] | ||
| - | [[Category: Aza]] | ||
| - | [[Category: Fla]] | ||
| - | [[Category: Fluorinase]] | ||
| - | [[Category: Inhibitor]] | ||
| - | [[Category: Sam analogue]] | ||
[[Category: Streptomyces cattleya]] | [[Category: Streptomyces cattleya]] | ||
| - | [[Category: | + | [[Category: Deng H]] |
| + | [[Category: McEwan AR]] | ||
| + | [[Category: McGlinchey RP]] | ||
| + | [[Category: Naismith JH]] | ||
| + | [[Category: O'Hagan D]] | ||
| + | [[Category: Robinson DR]] | ||
Current revision
X-ray crystal structure of 5'-fluorodeoxyadenosine synthase from Streptomyces cattleya complexed with an inhibitor, an analogue of S- adenosyl methionine
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