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1uvh

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<StructureSection load='1uvh' size='340' side='right'caption='[[1uvh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='1uvh' size='340' side='right'caption='[[1uvh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uvh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UVH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uvh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UVH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uvh OCA], [http://pdbe.org/1uvh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1uvh RCSB], [http://www.ebi.ac.uk/pdbsum/1uvh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1uvh ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uvh OCA], [https://pdbe.org/1uvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uvh RCSB], [https://www.ebi.ac.uk/pdbsum/1uvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uvh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPS_MYCSM DPS_MYCSM] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). It protects DNA from hydroxyl radical-mediated cleavage. Binds DNA with no apparent sequence specificity without self-aggregation nor promotion of DNA condensation. Is unable to protect DNA from DNase-mediated cleavage.<ref>PMID:12466274</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 1uvh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1uvh" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ferritin 3D structures|Ferritin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus smegmatis trevisan 1889]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ceci, P]]
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[[Category: Mycolicibacterium smegmatis]]
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[[Category: Chiancone, E]]
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[[Category: Ceci P]]
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[[Category: Falvo, E]]
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[[Category: Chiancone E]]
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[[Category: Ilari, A]]
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[[Category: Falvo E]]
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[[Category: Dna binding protein]]
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[[Category: Ilari A]]
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[[Category: Dna protection from oxidative damage]]
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Current revision

X-ray structure of Dps from Mycobacterium smegmatis

PDB ID 1uvh

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