6nb7
From Proteopedia
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==SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)== | ==SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)== | ||
| - | < | + | <SX load='6nb7' size='340' side='right' viewer='molstar' caption='[[6nb7]], [[Resolution|resolution]] 4.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6nb7]] is a 9 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6nb7]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome-related_coronavirus Severe acute respiratory syndrome-related coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NB7 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nb7 OCA], [https://pdbe.org/6nb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nb7 RCSB], [https://www.ebi.ac.uk/pdbsum/6nb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nb7 ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/SPIKE_CVHSA SPIKE_CVHSA]] S1 attaches the virion to the cell membrane by interacting with human ACE2 and CLEC4M/DC-SIGNR, initiating the infection. Binding to the receptor and internalization of the virus into the endosomes of the host cell probably induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes. S2 is a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6nb7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6nb7" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[Sandbox 3001|Sandbox 3001]] | ||
| + | *[[Spike protein 3D structures|Spike protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cameroni | + | [[Category: Severe acute respiratory syndrome-related coronavirus]] |
| - | [[Category: Corti | + | [[Category: Cameroni E]] |
| - | [[Category: Gopal | + | [[Category: Corti D]] |
| - | [[Category: Lanzavecchia | + | [[Category: Gopal R]] |
| - | [[Category: Mian | + | [[Category: Lanzavecchia A]] |
| - | [[Category: Park | + | [[Category: Mian D]] |
| - | [[Category: Quispe | + | [[Category: Park YJ]] |
| - | [[Category: Rey | + | [[Category: Quispe J]] |
| - | + | [[Category: Rey FA]] | |
| - | [[Category: Snijder | + | [[Category: Snijder S]] |
| - | [[Category: Tortorici | + | [[Category: Tortorici MA]] |
| - | [[Category: Veesler | + | [[Category: Veesler D]] |
| - | [[Category: Walls | + | [[Category: Walls AC]] |
| - | [[Category: Xiong | + | [[Category: Xiong X]] |
| - | [[Category: Zambon | + | [[Category: Zambon M]] |
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Current revision
SARS-CoV complex with human neutralizing S230 antibody Fab fragment (state 2)
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