This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2izs
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='2izs' size='340' side='right'caption='[[2izs]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='2izs' size='340' side='right'caption='[[2izs]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2izs]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2izs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZS FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BRQ:{[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE'>BRQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRQ:{[4-AMINO-2-(3-CHLOROANILINO)-1,3-THIAZOL-5-YL](4-FLUOROPHENYL)METHANONE'>BRQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izs OCA], [https://pdbe.org/2izs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izs RCSB], [https://www.ebi.ac.uk/pdbsum/2izs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izs ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/KC1G3_HUMAN KC1G3_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 26: | Line 25: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Arrowsmith C]] | |
| - | [[Category: Arrowsmith | + | [[Category: Bunkoczi G]] |
| - | [[Category: Bunkoczi | + | [[Category: Das S]] |
| - | [[Category: Das | + | [[Category: Debreczeni JE]] |
| - | [[Category: Debreczeni | + | [[Category: Edwards A]] |
| - | + | [[Category: Fedorov O]] | |
| - | [[Category: Edwards | + | [[Category: Gileadi O]] |
| - | [[Category: Fedorov | + | [[Category: Knapp S]] |
| - | [[Category: Gileadi | + | [[Category: Rellos P]] |
| - | [[Category: Knapp | + | [[Category: Salah E]] |
| - | [[Category: Rellos | + | [[Category: Savitsky P]] |
| - | [[Category: Salah | + | [[Category: Sundstrom M]] |
| - | [[Category: Savitsky | + | [[Category: Weigelt J]] |
| - | [[Category: Sundstrom | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Structure of casein kinase gamma 3 in complex with inhibitor
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith C | Bunkoczi G | Das S | Debreczeni JE | Edwards A | Fedorov O | Gileadi O | Knapp S | Rellos P | Salah E | Savitsky P | Sundstrom M | Weigelt J | Von Delft F
