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| | <StructureSection load='2rf6' size='340' side='right'caption='[[2rf6]], [[Resolution|resolution]] 1.95Å' scene=''> | | <StructureSection load='2rf6' size='340' side='right'caption='[[2rf6]], [[Resolution|resolution]] 1.95Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2rf6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RF6 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2rf6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2p4d|2p4d]], [[2q05|2q05]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf6 OCA], [http://pdbe.org/2rf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rf6 RCSB], [http://www.ebi.ac.uk/pdbsum/2rf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf6 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf6 OCA], [https://pdbe.org/2rf6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf6 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW]] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref> | + | [https://www.uniprot.org/uniprot/DUSP_VACCW DUSP_VACCW] Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.<ref>PMID:10438817</ref> <ref>PMID:11238845</ref> <ref>PMID:1848923</ref> <ref>PMID:18593332</ref> <ref>PMID:21362620</ref> |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | ==See Also== | | ==See Also== |
| - | *[[MAP kinase phosphatase|MAP kinase phosphatase]] | + | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
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| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| | [[Category: Vaccinia virus]] | | [[Category: Vaccinia virus]] |
| - | [[Category: Cingolani, G]] | + | [[Category: Cingolani G]] |
| - | [[Category: Koksal, A C]] | + | [[Category: Koksal AC]] |
| - | [[Category: Dual-specificity phosphatase]]
| + | |
| - | [[Category: Hydrolase]]
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| - | [[Category: Late protein]]
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| - | [[Category: Protein phosphatase]]
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| - | [[Category: Vh1]]
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| Structural highlights
Function
DUSP_VACCW Serine/Tyrosine phosphatase which down-regulates cellular antiviral response by dephosphorylating activated host STAT1 and blocking interferon (IFN)-stimulated innate immune responses. Dephosphorylates the A17 protein.[1] [2] [3] [4] [5]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Derrien M, Punjabi A, Khanna M, Grubisha O, Traktman P. Tyrosine phosphorylation of A17 during vaccinia virus infection: involvement of the H1 phosphatase and the F10 kinase. J Virol. 1999 Sep;73(9):7287-96. PMID:10438817
- ↑ Najarro P, Traktman P, Lewis JA. Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation. J Virol. 2001 Apr;75(7):3185-96. PMID:11238845 doi:http://dx.doi.org/10.1128/JVI.75.7.3185-3196.2001
- ↑ Guan KL, Broyles SS, Dixon JE. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature. 1991 Mar 28;350(6316):359-62. PMID:1848923 doi:http://dx.doi.org/10.1038/350359a0
- ↑ Mann BA, Huang JH, Li P, Chang HC, Slee RB, O'Sullivan A, Anita M, Yeh N, Klemsz MJ, Brutkiewicz RR, Blum JS, Kaplan MH. Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res. 2008 Jun;28(6):367-80. doi: 10.1089/jir.2007.0113. PMID:18593332 doi:http://dx.doi.org/10.1089/jir.2007.0113
- ↑ Koksal AC, Cingolani G. Dimerization of Vaccinia virus VH1 is essential for dephosphorylation of STAT1 at tyrosine 701. J Biol Chem. 2011 Apr 22;286(16):14373-82. doi: 10.1074/jbc.M111.226357. Epub, 2011 Mar 1. PMID:21362620 doi:http://dx.doi.org/10.1074/jbc.M111.226357
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