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| | <StructureSection load='1vs2' size='340' side='right'caption='[[1vs2]], [[Resolution|resolution]] 2.00Å' scene=''> | | <StructureSection load='1vs2' size='340' side='right'caption='[[1vs2]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1vs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomycineae Streptomycineae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VS2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1vs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp. Streptomyces sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VS2 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene>, <scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[185d|185d]], [[193d|193d]], [[1pfe|1pfe]], [[1xvk|1xvk]], [[1xvn|1xvn]], [[1xvr|1xvr]], [[2adw|2adw]], [[2da8|2da8]], [[3go3|3go3]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vs2 OCA], [https://pdbe.org/1vs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vs2 RCSB], [https://www.ebi.ac.uk/pdbsum/1vs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vs2 ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vs2 OCA], [http://pdbe.org/1vs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1vs2 RCSB], [http://www.ebi.ac.uk/pdbsum/1vs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1vs2 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Streptomycineae]] | + | [[Category: Streptomyces sp]] |
| - | [[Category: Quigley, G J]] | + | [[Category: Quigley GJ]] |
| - | [[Category: Rich, A]] | + | [[Category: Rich A]] |
| - | [[Category: Ughetto, G]] | + | [[Category: Ughetto G]] |
| - | [[Category: Wang, A H.J]] | + | [[Category: Wang AH-J]] |
| - | [[Category: Antibiotic]]
| + | |
| - | [[Category: Antitumor]]
| + | |
| - | [[Category: Bisintercalator]]
| + | |
| - | [[Category: Desipeptide]]
| + | |
| - | [[Category: Dna-antibiotic complex]]
| + | |
| - | [[Category: Quinoxaline]]
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| Structural highlights
Publication Abstract from PubMed
The crystal structure of a DNA octamer d(GCGTACGC) complexed to an antitumor antibiotic, triostin A, has been solved and refined to 2.2 A resolution by x-ray diffraction analysis. The antibiotic molecule acts as a true bis intercalator surrounding the d(CpG) sequence at either end of the unwound right-handed DNA double helix. As previously observed in the structure of triostin A-d(CGTACG) complex (A.H.-J. Wang, et. al., Science, 225, 1115-1121 (1984)), the alanine amino acid residues of the drug molecule form sequence-specific hydrogen bonds to guanines in the minor groove. The two central A.T base pairs are in Hoogsteen configuration with adenine in the syn conformation. In addition, the two terminal G.C base pairs flanking the quinoxaline rings are also held together by Hoogsteen base pairing. This is the first observation in an oligonucleotide of. Hoogsteen G.C base pairs where the cytosine is protonated. The principal functional components of a bis-intercalative compound are discussed.
Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex.,Wang AH, Ughetto G, Quigley GJ, Rich A J Biomol Struct Dyn. 1986 Dec;4(3):319-42. PMID:3271447[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Wang AH, Ughetto G, Quigley GJ, Rich A. Interactions of quinoxaline antibiotic and DNA: the molecular structure of a triostin A-d(GCGTACGC) complex. J Biomol Struct Dyn. 1986 Dec;4(3):319-42. PMID:3271447
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