6lqi

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(New page: '''Unreleased structure''' The entry 6lqi is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (10:47, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6lqi is ON HOLD
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==Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1==
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<SX load='6lqi' size='340' side='right' viewer='molstar' caption='[[6lqi]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lqi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LQI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LQI FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lqi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lqi OCA], [https://pdbe.org/6lqi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lqi RCSB], [https://www.ebi.ac.uk/pdbsum/6lqi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lqi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Geng J]]
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[[Category: Li X]]
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[[Category: Liu W]]
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[[Category: Shen B]]
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[[Category: Wang L]]
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[[Category: Xiao B]]
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[[Category: Zhang M]]
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[[Category: Zhang T]]
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[[Category: Zhou H]]

Current revision

Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1

6lqi, resolution 4.50Å

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