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6lry

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6lry is ON HOLD
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==Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b==
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<StructureSection load='6lry' size='340' side='right'caption='[[6lry]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atractaspis_engaddensis Atractaspis engaddensis], [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB59 Enterobacteria phage RB59] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LRY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lry OCA], [https://pdbe.org/6lry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lry RCSB], [https://www.ebi.ac.uk/pdbsum/6lry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lry ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Hirschsprung disease;Waardenburg-Shah syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Defects in EDNRB are associated with Waardenburg syndrome 2, with ocular albinism, autosomal recessive: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis.<ref>PMID:28236341</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:7536888</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sarafotoxins (SRTXs) are endothelin-like peptides extracted from snake venom. SRTXs stimulate the endothelin ETA and ETB receptors and enhance vasoconstriction, followed by left ventricular dysfunction and bronchoconstriction. SRTXs include four major isopeptides, S6a-d, with different subtype selectivities. Here, we report the crystal structure of the human ETB receptor in complex with the non-selective sarafotoxin S6b at 3.0 A resolution. This structure reveals the similarities and differences between the binding modes of the endothelins and S6b. Moreover, molecular dynamics simulations based on the S6b-bound receptor provides structural insight into the subtype selectivity of the sarafotoxins. Our study clarifies the recognition mechanism of the endothelin-like peptide families.
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Authors: Izume, T., Miyauchi, H., Shihoya, W., Nureki, O.
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Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b.,Izume T, Miyauchi H, Shihoya W, Nureki O Biochem Biophys Res Commun. 2020 Jan 28. pii: S0006-291X(20)30021-8. doi:, 10.1016/j.bbrc.2019.12.091. PMID:32001000<ref>PMID:32001000</ref>
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Description: Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Nureki, O]]
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<div class="pdbe-citations 6lry" style="background-color:#fffaf0;"></div>
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[[Category: Miyauchi, H]]
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== References ==
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[[Category: Izume, T]]
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<references/>
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[[Category: Shihoya, W]]
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__TOC__
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</StructureSection>
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[[Category: Atractaspis engaddensis]]
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[[Category: Enterobacteria phage RB59]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Izume T]]
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[[Category: Miyauchi H]]
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[[Category: Nureki O]]
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[[Category: Shihoya W]]

Current revision

Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b

PDB ID 6lry

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