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6vg3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6vg3 is ON HOLD Authors: Stayrook, S.E., Lemmon, M.A., Malhotra, K. Description: Structure of unliganded, inactive PTK7 kinase domain [[Category: U...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of unliganded, inactive PTK7 kinase domain== | |
| - | + | <StructureSection load='6vg3' size='340' side='right'caption='[[6vg3]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vg3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VG3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vg3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vg3 OCA], [https://pdbe.org/6vg3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vg3 RCSB], [https://www.ebi.ac.uk/pdbsum/6vg3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vg3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Malhotra | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PTK7_HUMAN PTK7_HUMAN] Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.<ref>PMID:18471990</ref> <ref>PMID:20558616</ref> <ref>PMID:20837484</ref> <ref>PMID:21103379</ref> <ref>PMID:21132015</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lemmon MA]] | ||
| + | [[Category: Malhotra K]] | ||
| + | [[Category: Sheetz J]] | ||
| + | [[Category: Stayrook SE]] | ||
Current revision
Structure of unliganded, inactive PTK7 kinase domain
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