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6vip
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6vip is ON HOLD Authors: The, J., Hong, Z., Dong, A., Headey, S., Gunzburg, M., Doak, B., James, L.I., Bountra, C., Arrowsmith, C.H., Edwards, A.M.,...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008== | |
| - | + | <StructureSection load='6vip' size='340' side='right'caption='[[6vip]], [[Resolution|resolution]] 1.36Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VIP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=QXY:{4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone'>QXY</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vip OCA], [https://pdbe.org/6vip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vip RCSB], [https://www.ebi.ac.uk/pdbsum/6vip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vip ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Doak B]] | ||
| + | [[Category: Dong A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Gunzburg M]] | ||
| + | [[Category: Headey S]] | ||
| + | [[Category: Hong Z]] | ||
| + | [[Category: James LI]] | ||
| + | [[Category: The J]] | ||
Current revision
TUDOR DOMAIN OF TUMOR SUPPRESSOR P53BP1 WITH MFP-6008
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Brown PJ | Doak B | Dong A | Edwards AM | Gunzburg M | Headey S | Hong Z | James LI | The J
