6uen

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==Cryo-EM structure of the respiratory syncytial virus RNA polymerase==
==Cryo-EM structure of the respiratory syncytial virus RNA polymerase==
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<StructureSection load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
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<SX load='6uen' size='340' side='right' viewer='molstar' caption='[[6uen]], [[Resolution|resolution]] 3.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6uen]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UEN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.67&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [https://pdbe.org/6uen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [https://www.ebi.ac.uk/pdbsum/6uen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/G8EJ12_HRSV G8EJ12_HRSV]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830]
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[https://www.uniprot.org/uniprot/PHOSP_HRSVA PHOSP_HRSVA] Acts as a cofactor that serves both to stabilize the protein L and to place the polymerase complex on the N:RNA template.
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Human orthopneumovirus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cao, D]]
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[[Category: Cao D]]
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[[Category: Gao, Y]]
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[[Category: Gao Y]]
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[[Category: Liang, B]]
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[[Category: Liang B]]
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[[Category: Viral protein]]
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[[Category: Viral protein complex]]
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[[Category: Viral protein-transferase complex]]
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Current revision

Cryo-EM structure of the respiratory syncytial virus RNA polymerase

6uen, resolution 3.67Å

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OCA

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