1ltl

<table><tr><td colspan='2'>[[1ltl]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"methanobacterium_thermoautotrophicus"_(sic)_zeikus_and_wolfe_1972 "methanobacterium thermoautotrophicus" (sic) zeikus and wolfe 1972]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LTL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LTL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ltl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ltl OCA], [http://pdbe.org/1ltl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ltl RCSB], [http://www.ebi.ac.uk/pdbsum/1ltl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ltl ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Eukaryotic chromosomal DNA is licensed for replication precisely once in each cell cycle. The mini-chromosome maintenance (MCM) complex plays a role in this replication licensing. We have determined the structure of a fragment of MCM from Methanobacterium thermoautotrophicum (mtMCM), a model system for eukaryotic MCM. The structure reveals a novel dodecameric architecture with a remarkably long central channel. The channel surface has an unusually high positive charge and binds DNA. We also show that the structure of the N-terminal fragment is conserved for all MCMs proteins despite highly divergent sequences, suggesting a common architecture for a similar task: gripping/remodeling DNA and regulating MCM activity. An mtMCM mutant protein equivalent to a yeast MCM5 (CDC46) protein with the bob1 mutation at its N terminus has only subtle structural changes, suggesting a Cdc7-bypass mechanism by Bob1 in yeast. Yeast bypass experiments using MCM5 mutant proteins support the hypothesis for the bypass mechanism.

The structure and function of MCM from archaeal M. Thermoautotrophicum.,Fletcher RJ, Bishop BE, Leon RP, Sclafani RA, Ogata CM, Chen XS Nat Struct Biol. 2003 Mar;10(3):160-7. PMID:12548282<ref>PMID:12548282</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1ltl" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bishop, B E]]

[[Category: Chen, X S]]

[[Category: Fletcher, R J]]

[[Category: Leon, R P]]

[[Category: Ogata, C M]]

[[Category: Sclafani, R A]]

[[Category: Replication]]