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1ae5

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[[Image:1ae5.gif|left|200px]]
 
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==HUMAN HEPARIN BINDING PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1ae5", creates the "Structure Box" on the page.
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<StructureSection load='1ae5' size='340' side='right'caption='[[1ae5]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ae5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AE5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1ae5| PDB=1ae5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ae5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ae5 OCA], [https://pdbe.org/1ae5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ae5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ae5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ae5 ProSAT]</span></td></tr>
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</table>
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'''HUMAN HEPARIN BINDING PROTEIN'''
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== Function ==
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[https://www.uniprot.org/uniprot/CAP7_HUMAN CAP7_HUMAN] This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.<ref>PMID:1937776</ref> <ref>PMID:1399008</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/1ae5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ae5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
The structure of human heparin binding protein reveals that the serine proteinase fold has been used as a scaffold for a multifunctional protein with antibacterial activity, monocyte and t-cell activating properties and endotoxin and heparin binding capacity.
The structure of human heparin binding protein reveals that the serine proteinase fold has been used as a scaffold for a multifunctional protein with antibacterial activity, monocyte and t-cell activating properties and endotoxin and heparin binding capacity.
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==About this Structure==
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Structure of HBP, a multifunctional protein with a serine proteinase fold.,Iversen LF, Kastrup JS, Bjorn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ, Larsen IK Nat Struct Biol. 1997 Apr;4(4):265-8. PMID:9095193<ref>PMID:9095193</ref>
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1AE5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AE5 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structure of HBP, a multifunctional protein with a serine proteinase fold., Iversen LF, Kastrup JS, Bjorn SE, Rasmussen PB, Wiberg FC, Flodgaard HJ, Larsen IK, Nat Struct Biol. 1997 Apr;4(4):265-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9095193 9095193]
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</div>
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<div class="pdbe-citations 1ae5" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bjorn, S E.]]
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[[Category: Bjorn SE]]
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[[Category: Flodgaard, H J.]]
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[[Category: Flodgaard HJ]]
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[[Category: Iversen, L F.]]
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[[Category: Iversen LF]]
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[[Category: Kastrup, J S.]]
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[[Category: Kastrup JS]]
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[[Category: Larsen, I K.]]
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[[Category: Larsen IK]]
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[[Category: Rasmussen, P B.]]
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[[Category: Rasmussen PB]]
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[[Category: Wiberg, F C.]]
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[[Category: Wiberg FC]]
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[[Category: Antibacterial]]
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[[Category: Azurocidin]]
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[[Category: Cap37]]
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[[Category: Endotoxin binding]]
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[[Category: Glycosylated protein]]
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[[Category: Heparin binding]]
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[[Category: Inflammation]]
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[[Category: Serine protease homolog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:08:58 2008''
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Current revision

HUMAN HEPARIN BINDING PROTEIN

PDB ID 1ae5

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