6lt0

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'''Unreleased structure'''
 
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The entry 6lt0 is ON HOLD
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==cryo-EM structure of C9ORF72-SMCR8-WDR41==
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<StructureSection load='6lt0' size='340' side='right'caption='[[6lt0]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lt0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LT0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lt0 OCA], [https://pdbe.org/6lt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lt0 RCSB], [https://www.ebi.ac.uk/pdbsum/6lt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lt0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WDR41_HUMAN WDR41_HUMAN] Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).<ref>PMID:27103069</ref> <ref>PMID:27193190</ref> <ref>PMID:27617292</ref> <ref>PMID:28195531</ref>
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Authors:
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==See Also==
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*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Qi S]]
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[[Category: Sheng J]]
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[[Category: Tang D]]
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[[Category: Xu L]]
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[[Category: Yan C]]
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[[Category: Zhan X]]

Current revision

cryo-EM structure of C9ORF72-SMCR8-WDR41

PDB ID 6lt0

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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