6p4p
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Salmonella typhi PltB Homopentamer N29K Mutant== | |
| + | <StructureSection load='6p4p' size='340' side='right'caption='[[6p4p]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6p4p]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi_ct18 Salmonella enterica subsp. enterica serovar typhi ct18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P4P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6P4P FirstGlance]. <br> | ||
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STY1891, t1107 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220341 Salmonella enterica subsp. enterica serovar Typhi CT18])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p4p OCA], [http://pdbe.org/6p4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p4p RCSB], [http://www.ebi.ac.uk/pdbsum/6p4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p4p ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce different clinical presentations. The PltB subunit of each toxin exhibits different glycan-binding preferences that correlate with glycan expression profiles of host cells targeted by each bacterium at the primary infection or intoxication sites. Through co-crystal structures of PltB subunits bound to specific glycan receptor moieties, we show that they induce markedly different glycan-binding preferences and virulence outcomes. Furthermore, immunization with the NTS S. Javiana or its toxin offers cross-reactive protection against lethal-dose typhoid toxin challenge. Cumulatively, these results offer insights into the evolution of host adaptations in Salmonella AB toxins, their cell and tissue tropisms, and the design for improved typhoid vaccines and therapeutics. | ||
| - | + | Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.,Lee S, Yang YA, Milano SK, Nguyen T, Ahn C, Sim JH, Thompson AJ, Hillpot EC, Yoo G, Paulson JC, Song J Cell Host Microbe. 2020 Jun 10;27(6):937-949.e6. doi: 10.1016/j.chom.2020.04.005., Epub 2020 May 11. PMID:32396840<ref>PMID:32396840</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6p4p" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar typhi ct18]] | ||
| + | [[Category: Hillpot, E C]] | ||
| + | [[Category: Milano, S K]] | ||
| + | [[Category: Nguyen, T]] | ||
| + | [[Category: Song, J]] | ||
| + | [[Category: Yang, Y A]] | ||
| + | [[Category: Pltb]] | ||
| + | [[Category: Toxin]] | ||
Current revision
Salmonella typhi PltB Homopentamer N29K Mutant
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