6uht
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10== | |
| - | + | <StructureSection load='6uht' size='340' side='right'caption='[[6uht]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uht]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UHT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UHT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2000146Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uht OCA], [https://pdbe.org/6uht PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uht RCSB], [https://www.ebi.ac.uk/pdbsum/6uht PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uht ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Clostridium botulinum]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vicugna pacos]] | ||
| + | [[Category: Jin R]] | ||
| + | [[Category: Lam K]] | ||
Current revision
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10
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