6ul4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11== | |
| + | <StructureSection load='6ul4' size='340' side='right'caption='[[6ul4]], [[Resolution|resolution]] 3.18Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ul4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UL4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1842434Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ul4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ul4 OCA], [https://pdbe.org/6ul4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ul4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ul4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ul4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| - | + | ==See Also== | |
| - | + | *[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Clostridium botulinum]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vicugna pacos]] | ||
| + | [[Category: Jin R]] | ||
| + | [[Category: Lam K]] | ||
Current revision
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLO-G11
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