6vcc
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the Dvl2 DIX filament== | |
| - | + | <StructureSection load='6vcc' size='340' side='right'caption='[[6vcc]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vcc]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VCC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vcc OCA], [https://pdbe.org/6vcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vcc RCSB], [https://www.ebi.ac.uk/pdbsum/6vcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vcc ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/DVL2_MOUSE DVL2_MOUSE] Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes.<ref>PMID:17199046</ref> <ref>PMID:21189423</ref> <ref>PMID:20947020</ref> |
| - | [[Category: Kan | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Weis | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chen DH]] | ||
| + | [[Category: Enos M]] | ||
| + | [[Category: Kan W]] | ||
| + | [[Category: Muennich S]] | ||
| + | [[Category: Skiniotis G]] | ||
| + | [[Category: Weis WI]] | ||
Current revision
Cryo-EM structure of the Dvl2 DIX filament
| |||||||||||
Categories: Large Structures | Mus musculus | Chen DH | Enos M | Kan W | Muennich S | Skiniotis G | Weis WI
