6qbi
From Proteopedia
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==NMR structure of BB_P28, Borrelia burgdorferi outer surface lipoprotein== | ==NMR structure of BB_P28, Borrelia burgdorferi outer surface lipoprotein== | ||
| - | <StructureSection load='6qbi' size='340' side='right'caption='[[6qbi | + | <StructureSection load='6qbi' size='340' side='right'caption='[[6qbi]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6qbi]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QBI OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6qbi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_B31 Borreliella burgdorferi B31]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QBI FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qbi OCA], [https://pdbe.org/6qbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qbi RCSB], [https://www.ebi.ac.uk/pdbsum/6qbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qbi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MLPA_BORBU MLPA_BORBU] An outer membrane protein that may participate in pathogenesis. Some human Lyme disease patients have antibodies against this protein (PubMed:10948116). The Mlp proteins probably undergo intragenic recombination, generating new alleles (Probable).<ref>PMID:10948116</ref> <ref>PMID:10948116</ref> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Lyme disease is the most widespread vector-transmitted disease in North America and Europe, caused by infection with Borrelia burgdorferi sensu lato complex spirochetes. We report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBP28, a member of the multicopy lipoprotein (mlp) family. The structure comprises a tether peptide, five alpha-helices and an extended C-terminal loop. The fold is similar to that of Borrelia turicatae outer surface protein BTA121, which is known to bind lipids. These results contribute to the understanding of Lyme disease pathogenesis by revealing the molecular structure of a protein from the widely found mlp family. | ||
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| + | Solution NMR structure of Borrelia burgdorferi outer surface lipoprotein BBP28, a member of the mlp protein family.,Fridmanis J, Otikovs M, Brangulis K, Tars K, Jaudzems K Proteins. 2021 May;89(5):588-594. doi: 10.1002/prot.26011. Epub 2020 Sep 28. PMID:32949018<ref>PMID:32949018</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6qbi" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Borreliella burgdorferi B31]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brangulis | + | [[Category: Brangulis K]] |
| - | [[Category: Fridmanis | + | [[Category: Fridmanis J]] |
| - | [[Category: Jaudzems | + | [[Category: Jaudzems K]] |
| - | [[Category: Otikovs | + | [[Category: Otikovs M]] |
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| - | + | ||
Current revision
NMR structure of BB_P28, Borrelia burgdorferi outer surface lipoprotein
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