This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6ir0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:51, 14 June 2023) (edit) (undo)
 
Line 1: Line 1:
==Zinc finger domain of the human DTX protein==
==Zinc finger domain of the human DTX protein==
-
<StructureSection load='6ir0' size='340' side='right'caption='[[6ir0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='6ir0' size='340' side='right'caption='[[6ir0]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6ir0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IR0 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6ir0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IR0 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ir0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ir0 OCA], [https://pdbe.org/6ir0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ir0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ir0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ir0 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ir0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ir0 OCA], [http://pdbe.org/6ir0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ir0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ir0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ir0 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/DTX2_HUMAN DTX2_HUMAN]] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
+
[https://www.uniprot.org/uniprot/DTX2_HUMAN DTX2_HUMAN] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: RING-type E3 ubiquitin transferase]]
+
[[Category: Miyamoto K]]
-
[[Category: Miyamoto, K]]
+
-
[[Category: Dtx]]
+
-
[[Category: Ligase]]
+
-
[[Category: Ring finger]]
+
-
[[Category: Zinc finger]]
+

Current revision

Zinc finger domain of the human DTX protein

PDB ID 6ir0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ir0"
Personal tools