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6tq6
From Proteopedia
(Difference between revisions)
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<StructureSection load='6tq6' size='340' side='right'caption='[[6tq6]], [[Resolution|resolution]] 2.55Å' scene=''> | <StructureSection load='6tq6' size='340' side='right'caption='[[6tq6]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6tq6]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6tq6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TQ6 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NVH:2-(5-methylsulfonylpyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one'>NVH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.546Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NVH:2-(5-methylsulfonylpyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one'>NVH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tq6 OCA], [https://pdbe.org/6tq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tq6 RCSB], [https://www.ebi.ac.uk/pdbsum/6tq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tq6 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6tq6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6tq6" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Orexin and Orexin receptor|Orexin and Orexin receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ali | + | [[Category: Ali A]] |
| - | [[Category: Bennett | + | [[Category: Bennett KA]] |
| - | [[Category: Brown | + | [[Category: Brown JD]] |
| - | [[Category: Bucknell | + | [[Category: Bucknell SJ]] |
| - | [[Category: Christopher | + | [[Category: Christopher JA]] |
| - | [[Category: Congreve | + | [[Category: Congreve M]] |
| - | [[Category: Cooke | + | [[Category: Cooke RM]] |
| - | [[Category: Cseke | + | [[Category: Cseke G]] |
| - | [[Category: Dore | + | [[Category: Dore AS]] |
| - | [[Category: Errey | + | [[Category: Errey JC]] |
| - | + | [[Category: Jazayeri A]] | |
| - | [[Category: Jazayeri | + | [[Category: Marshall FH]] |
| - | [[Category: Marshall | + | [[Category: Mason JS]] |
| - | [[Category: Mason | + | [[Category: Mould R]] |
| - | [[Category: Mould | + | [[Category: Patel JC]] |
| - | [[Category: Patel | + | [[Category: Rappas M]] |
| - | [[Category: Rappas | + | [[Category: Tehan BG]] |
| - | [[Category: Tehan | + | [[Category: Weir M]] |
| - | [[Category: Weir | + | [[Category: De Graaf C]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of the Orexin-1 receptor in complex with Compound 14
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Categories: Homo sapiens | Large Structures | Ali A | Bennett KA | Brown JD | Bucknell SJ | Christopher JA | Congreve M | Cooke RM | Cseke G | Dore AS | Errey JC | Jazayeri A | Marshall FH | Mason JS | Mould R | Patel JC | Rappas M | Tehan BG | Weir M | De Graaf C
