1z3q

From Proteopedia

(Difference between revisions)

Current revision

Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A

Structural highlights

1z3q is a 1 chain structure with sequence from Musa acuminata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.7Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O22322_MUSAC

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The structure of a thaumatin-like protein from banana (Musa acuminata) fruit, an allergen with antifungal properties, was solved at 1.7-A-resolution, by X-ray crystallography. Though the banana protein exhibits a very similar overall fold as thaumatin it markedly differs from the sweet-tasting protein by the presence of a surface exposed electronegative cleft. Due to the presence of this electronegative cleft, the banana thaumatin-like protein (Ban-TLP) acquires a strong (local) electronegative character that eventually explains the observed antifungal activity. Our structural analysis also revealed the presence of conserved residues of exposed epitopic determinants that are presumably responsible for the allergenic properties of banana fruit towards susceptible individuals, and provided evidence that the Ban-TLP shares some structurally highly conserved IgE-binding epitopes with thaumatin-like proteins from fruits or pollen from other plants. In addition, some overlap was detected between the predicted IgE-binding epitopes of the Ban-TLP and IgE-binding epitopes previously identified in the mountain cedar Jun a 3 TLP aeroallergen. The presence of these common epitopes offers a molecular basis for the cross-reactivity between aeroallergens and fruit allergens.

Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A.,Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P Biochimie. 2006 Jan;88(1):45-52. Epub 2005 Aug 8. PMID:16085352^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P. Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A. Biochimie. 2006 Jan;88(1):45-52. Epub 2005 Aug 8. PMID:16085352 doi:http://dx.doi.org/10.1016/j.biochi.2005.07.001

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z3q"

@@ Line 3: / Line 3: @@
 <StructureSection load='1z3q' size='340' side='right'caption='[[1z3q]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1z3q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Z3Q FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1z3q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Musa_acuminata Musa acuminata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3Q FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3q OCA], [http://pdbe.org/1z3q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1z3q RCSB], [http://www.ebi.ac.uk/pdbsum/1z3q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3q ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3q OCA], [https://pdbe.org/1z3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3q RCSB], [https://www.ebi.ac.uk/pdbsum/1z3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3q ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O22322_MUSAC O22322_MUSAC]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 12: / Line 15: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z3/1z3q_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 32: / Line 35: @@
 [[Category: Large Structures]]
 [[Category: Musa acuminata]]
-[[Category: Barre, A]]
+[[Category: Barre A]]
-[[Category: Damme, E J.M Van]]
+[[Category: Leone P]]
-[[Category: Leone, P]]
+[[Category: Menu-Bouaouiche L]]
-[[Category: Menu-Bouaouiche, L]]
+[[Category: Payan F]]
-[[Category: Payan, F]]
+[[Category: Peumans WJ]]
-[[Category: Peumans, W J]]
+[[Category: Rouge P]]
-[[Category: Rouge, P]]
+[[Category: Roussel A]]
-[[Category: Roussel, A]]
+[[Category: Van Damme EJM]]
-[[Category: Antifungal protein]]
-[[Category: Beta sandwich]]

1z3q

From Proteopedia

Current revision

Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7A

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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