1xxr

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<StructureSection load='1xxr' size='340' side='right'caption='[[1xxr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='1xxr' size='340' side='right'caption='[[1xxr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1xxr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XXR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1xxr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1xxq|1xxq]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxr OCA], [http://pdbe.org/1xxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xxr RCSB], [http://www.ebi.ac.uk/pdbsum/1xxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxr OCA], [https://pdbe.org/1xxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxr RCSB], [https://www.ebi.ac.uk/pdbsum/1xxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8LGR3_MORNI Q8LGR3_MORNI]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxr ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxr ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
 
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== Publication Abstract from PubMed ==
 
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The structures of MornigaM and the MornigaM-mannose complex have been determined at 1.8 A and 2.0 A resolution, respectively. Both structures adopt the typical beta-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbohydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure-function relationships within the small group of Moraceae lectins.
 
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Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose.,Rabijns A, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Rouge P FEBS J. 2005 Jul;272(14):3725-32. PMID:16008570<ref>PMID:16008570</ref>
 
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
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</div>
 
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<div class="pdbe-citations 1xxr" style="background-color:#fffaf0;"></div>
 
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Morus nigra]]
[[Category: Morus nigra]]
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[[Category: Barre, A]]
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[[Category: Barre A]]
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[[Category: Damme, E J.M Van]]
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[[Category: De Ranter CJ]]
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[[Category: Peumans, W J]]
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[[Category: Peumans WJ]]
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[[Category: Rabijns, A]]
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[[Category: Rabijns A]]
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[[Category: Ranter, C J.De]]
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[[Category: Rouge P]]
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[[Category: Rouge, P]]
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[[Category: Van Damme EJM]]
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[[Category: Sugar binding protein]]
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[[Category: Tetrameric b-prism fold]]
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Current revision

Structure of a mannose-specific jacalin-related lectin from Morus Nigra in complex with mannose

PDB ID 1xxr

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