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4bqu

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<StructureSection load='4bqu' size='340' side='right'caption='[[4bqu]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
<StructureSection load='4bqu' size='340' side='right'caption='[[4bqu]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bqu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brown_ear_tick Brown ear tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BQU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bqu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhipicephalus_appendiculatus Rhipicephalus appendiculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BQU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqu OCA], [http://pdbe.org/4bqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bqu RCSB], [http://www.ebi.ac.uk/pdbsum/4bqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqu ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bqu OCA], [https://pdbe.org/4bqu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bqu RCSB], [https://www.ebi.ac.uk/pdbsum/4bqu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bqu ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/JAP_RHIAP JAP_RHIAP] Salivary tick protein that modulates host immune response. This protein blocks dendritic cell (DC) differentiation from monocytes (PubMed:23825947). In addition, it inhibits up-regulation of costimulatory molecules and pro-inflammatory cytokines in response to stimuli and promotes up-regulation of co-inhibitory molecules and the anti-inflammatory cytokine interleukin-10 (PubMed:23825947). It has a pocket to accomodate cholesterol, which may have immune-modulatory roles, either directly or through interactions with the host gut microbiota (Probable).<ref>PMID:23825947</ref> <ref>PMID:29167574</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brown ear tick]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Austyn, J M]]
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[[Category: Rhipicephalus appendiculatus]]
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[[Category: Johnson, S]]
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[[Category: Austyn JM]]
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[[Category: Lea, S M]]
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[[Category: Johnson S]]
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[[Category: Nuttall, P]]
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[[Category: Lea SM]]
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[[Category: Preston, S]]
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[[Category: Nuttall P]]
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[[Category: Roversi, P]]
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[[Category: Preston S]]
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[[Category: Cholesterol-binding protein]]
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[[Category: Roversi P]]
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[[Category: Tick]]
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Current revision

Japanin from Rhipicephalus appendiculatus bound to cholesterol: Orthorhombic crystal form

PDB ID 4bqu

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