6xy4
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6xy4 is ON HOLD Authors: Suraweera, C.D., Hinds, M.G., Kvansakul, M. Description: Structural insight into sheep-pox virus mediated inhibition of ap...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural insight into sheep-pox virus mediated inhibition of apoptosis== | |
| + | <StructureSection load='6xy4' size='340' side='right'caption='[[6xy4]], [[Resolution|resolution]] 2.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6xy4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sheeppox_virus_(strain_TU-V02127) Sheeppox virus (strain TU-V02127)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XY4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0462315Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xy4 OCA], [https://pdbe.org/6xy4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xy4 RCSB], [https://www.ebi.ac.uk/pdbsum/6xy4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xy4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A3F2YKH3_SHEVT A0A3F2YKH3_SHEVT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Programmed death of infected cells is used by multicellular organisms to counter viral infections. Sheeppox virus encodes for SPPV14, a potent inhibitor of Bcl-2-mediated apoptosis. We reveal the structural basis of apoptosis inhibition by determining crystal structures of SPPV14 bound to BH3 motifs of proapoptotic Bax and Hrk. The structures show that SPPV14 engages BH3 peptides using the canonical ligand-binding groove. Unexpectedly, Arg84 from SPPV14 forms an ionic interaction with the conserved Asp in the BH3 motif in a manner that replaces the canonical ionic interaction seen in almost all host Bcl-2:BH3 motif complexes. These results reveal the flexibility of virus-encoded Bcl-2 proteins to mimic key interactions from endogenous host signalling pathways to retain BH3 binding and prosurvival functionality. | ||
| - | + | Crystal structures of the sheeppox virus encoded inhibitor of apoptosis SPPV14 bound to the proapoptotic BH3 peptides Hrk and Bax.,Suraweera CD, Burton DR, Hinds MG, Kvansakul M FEBS Lett. 2020 Jun;594(12):2016-2026. doi: 10.1002/1873-3468.13807. Epub 2020 , May 30. PMID:32390192<ref>PMID:32390192</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6xy4" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hinds MG]] | ||
| + | [[Category: Kvansakul M]] | ||
| + | [[Category: Suraweera CD]] | ||
Current revision
Structural insight into sheep-pox virus mediated inhibition of apoptosis
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