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4gj4

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<StructureSection load='4gj4' size='340' side='right'caption='[[4gj4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4gj4' size='340' side='right'caption='[[4gj4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gj4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Carolina_sphinx Carolina sphinx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GJ4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gj4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GJ4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gj4 OCA], [http://pdbe.org/4gj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gj4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gj4 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gj4 OCA], [https://pdbe.org/4gj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gj4 RCSB], [https://www.ebi.ac.uk/pdbsum/4gj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gj4 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/O77105_MANSE O77105_MANSE]
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Soluble guanylate cyclase (sGC) is a heterodimeric heme protein of ~150 kDa and the primary nitric oxide receptor. Binding of NO stimulates cyclase activity, leading to regulation of cardiovascular physiology and providing attractive opportunities for drug discovery. How sGC is stimulated and where candidate drugs bind remains unknown. The alpha and beta sGC chains are each composed of Heme-Nitric Oxide Oxygen (H-NOX), Per-ARNT-Sim (PAS), coiled-coil and cyclase domains. Here, we present the crystal structure of the alpha1 PAS domain to 1.8 A resolution. The structure reveals the binding surfaces of importance to heterodimer function, particularly with respect to regulating NO binding to heme in the beta1 H-NOX domain. It also reveals a small internal cavity that may serve to bind ligands or participate in signal transduction.
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Crystal structure of the alpha subunit PAS domain from soluble guanylyl cyclase.,Purohit R, Weichsel A, Montfort WR Protein Sci. 2013 Aug 12. doi: 10.1002/pro.2331. PMID:23934793<ref>PMID:23934793</ref>
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==See Also==
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*[[Guanylate cyclase 3D structures|Guanylate cyclase 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4gj4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carolina sphinx]]
 
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[[Category: Guanylate cyclase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Montfort, W R]]
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[[Category: Manduca sexta]]
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[[Category: Purohit, R]]
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[[Category: Montfort WR]]
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[[Category: Weichsel, A]]
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[[Category: Purohit R]]
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[[Category: Allosteric regulation]]
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[[Category: Weichsel A]]
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[[Category: Cgmp]]
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[[Category: Lyase]]
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[[Category: Nitric oxide]]
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[[Category: Pas domain]]
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[[Category: Pas fold]]
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[[Category: Yc-1]]
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Current revision

The Crystal Structure of the soluble Guanylate Cyclase PAS alpha domain from Manduca sexta

PDB ID 4gj4

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