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| | <StructureSection load='1zu5' size='340' side='right'caption='[[1zu5]], [[Resolution|resolution]] 2.40Å' scene=''> | | <StructureSection load='1zu5' size='340' side='right'caption='[[1zu5]], [[Resolution|resolution]] 2.40Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1zu5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"asterococcus_mycoides"_borrel_et_al._1910 "asterococcus mycoides" borrel et al. 1910]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZU5 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1zu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_mycoides Mycoplasma mycoides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZU5 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zu4|1zu4]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zu5 OCA], [http://pdbe.org/1zu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1zu5 RCSB], [http://www.ebi.ac.uk/pdbsum/1zu5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1zu5 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zu5 OCA], [https://pdbe.org/1zu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zu5 RCSB], [https://www.ebi.ac.uk/pdbsum/1zu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zu5 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/FTSY_MYCMS FTSY_MYCMS] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).[HAMAP-Rule:MF_00920] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Asterococcus mycoides borrel et al. 1910]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Gariani, T]] | + | [[Category: Mycoplasma mycoides]] |
| - | [[Category: Samuelsson, T]] | + | [[Category: Gariani T]] |
| - | [[Category: Sauer-Eriksson, A E]] | + | [[Category: Samuelsson T]] |
| - | [[Category: Ftsy]] | + | [[Category: Sauer-Eriksson AE]] |
| - | [[Category: Gtpase]]
| + | |
| - | [[Category: Protein transport]]
| + | |
| - | [[Category: Receptor]]
| + | |
| - | [[Category: Signal recognition particle]]
| + | |
| - | [[Category: Srp]]
| + | |
| Structural highlights
Function
FTSY_MYCMS Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).[HAMAP-Rule:MF_00920]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The prokaryotic signal recognition particle Ffh and its receptor FtsY allow targeting of proteins into or across the plasma membrane. The targeting process is GTP dependent and the two proteins constitute a distinct GTPase family. The receptor FtsY is composed of A and NG domains where the NG's GTPase domain plays a critical role in the targeting process. In this study, we describe two X-ray structures determined independently of each other of the NG domain of FtsY from Mycoplasma mycoides (MmFtsY). The two structures are markedly different in three of the nucleotide-binding segments, GI (P-loop), GII, and GIII, making only one of the structures compatible with nucleotide binding. Interestingly, the two distinct conformations of the nucleotide-binding segments of MmFtsY are similar to the apo- and ADP-loaded forms of certain ATPases. The structure of the extended interface between the A and NG domains of MmFtsY provides new insights into the role of the A domain for phospholipid interaction.
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY.,Gariani T, Samuelsson T, Sauer-Eriksson AE J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Gariani T, Samuelsson T, Sauer-Eriksson AE. Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY. J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944 doi:http://dx.doi.org/10.1016/j.jsb.2005.10.003
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