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4ciw

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<StructureSection load='4ciw' size='340' side='right'caption='[[4ciw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4ciw' size='340' side='right'caption='[[4ciw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ciw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CIW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ciw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CIW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XH2:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-(2-HYDROXY)ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>XH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4civ|4civ]], [[4cix|4cix]], [[4ciy|4ciy]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XH2:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-(2-HYDROXY)ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>XH2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ciw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ciw OCA], [https://pdbe.org/4ciw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ciw RCSB], [https://www.ebi.ac.uk/pdbsum/4ciw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ciw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ciw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ciw OCA], [http://pdbe.org/4ciw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ciw RCSB], [http://www.ebi.ac.uk/pdbsum/4ciw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ciw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
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[https://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3-dehydroquinate dehydratase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Blanco, B]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Gonzalez-Bello, C]]
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[[Category: Blanco B]]
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[[Category: Hawkins, A R]]
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[[Category: Gonzalez-Bello C]]
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[[Category: Lamb, H]]
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[[Category: Hawkins AR]]
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[[Category: Llamas-Saiz, A L]]
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[[Category: Lamb H]]
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[[Category: Otero, J M]]
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[[Category: Llamas-Saiz AL]]
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[[Category: Peon, A]]
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[[Category: Otero JM]]
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[[Category: Raaij, M J.van]]
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[[Category: Peon A]]
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[[Category: Sedes, A]]
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[[Category: Sedes A]]
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[[Category: Bacterial protein]]
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[[Category: Van Raaij MJ]]
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[[Category: Inhibitor]]
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[[Category: Lyase]]
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[[Category: Protein binding]]
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[[Category: Shikimis acid pathway]]
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[[Category: Substrate specificity]]
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Current revision

Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with (1R,4R,5R)-1,4,5-trihydroxy-3-(2-hydroxy)ethylcyclohex-2-ene-1-carboxylic acid

PDB ID 4ciw

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