1w9n

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==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
==Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis==
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<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1w9n' size='340' side='right'caption='[[1w9n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w9n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9N FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aj1|1aj1]], [[1mqx|1mqx]], [[1mqy|1mqy]], [[1mqz|1mqz]], [[1qow|1qow]], [[1wco|1wco]], [[2dde|2dde]], [[2ktn|2ktn]], [[2kto|2kto]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DBB:D-ALPHA-AMINOBUTYRIC+ACID'>DBB</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=PRD_000196:EPILANCIN+15X'>PRD_000196</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [http://pdbe.org/1w9n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [http://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9n OCA], [https://pdbe.org/1w9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9n RCSB], [https://www.ebi.ac.uk/pdbsum/1w9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9n ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/LAN15_STAEP LAN15_STAEP]
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The potential application of lantibiotics as food-preserving agents and more recently as antibiotics has strongly increased the interest in these antibacterial peptides. Here, we report the elucidation of the primary and three-dimensional structures of the novel lantibiotic epilancin 15X from Staphylococcus epidermidis using high-resolution nuclear magnetic resonance spectroscopy and tandem mass spectrometry. The molecule contains ten post-translationally modified amino acids, three lanthionine ring structures and a hydroxy-propionyl N-terminal moiety. The primary and tertiary structure and the distribution of positive charges are closely similar to the previously identified lantibiotic epilancin K7, most likely indicative of a common mode of action.
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Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis.,Ekkelenkamp MB, Hanssen M, Danny Hsu ST, de Jong A, Milatovic D, Verhoef J, van Nuland NA FEBS Lett. 2005 Mar 28;579(9):1917-22. PMID:15792796<ref>PMID:15792796</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1w9n" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Staphylococcus epidermidis]]
[[Category: Staphylococcus epidermidis]]
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[[Category: Ekkelenkamp, M]]
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[[Category: Ekkelenkamp M]]
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[[Category: Hanssen, M G.M]]
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[[Category: Hanssen MGM]]
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[[Category: Hsu, S T.D]]
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[[Category: Hsu S-TD]]
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[[Category: Jong, A de]]
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[[Category: Milatovic D]]
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[[Category: Milatovic, D]]
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[[Category: Verhoef J]]
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[[Category: Nuland, N A.J van]]
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[[Category: De Jong A]]
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[[Category: Verhoef, J]]
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[[Category: Van Nuland NAJ]]
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[[Category: Antibacterial]]
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[[Category: Antibiotic]]
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[[Category: Lanthionine]]
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[[Category: Thioester]]
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[[Category: Type a lantibiotic]]
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Current revision

Isolation and characterization of epilancin 15X, a novel antibiotic from a clinical strain of Staphylococcus epidermidis

PDB ID 1w9n

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