Syntrophin
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'> | <StructureSection load='1qav' size='350' side='right' caption='Mouse syntrophin PDZ domain (deepskyblue) complex with neuronal NOS (green) (PDB code [[1qav]])' scene='77/777075/Cv/1'> | ||
| - | + | __TOC__ | |
== Function == | == Function == | ||
'''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>. | '''Syntrophins''' (Syn) are a family of membrane-associated adaptor proteins which are important components of many signaling events: regulating the postsynaptic signal transduction, sarcolemmal localization of brain NOS and G-protein mediated signaling <ref>PMID:23263165</ref>. | ||
| + | *'''alpha-1-syntrophin''' is a cytoskeletal protein interacting with cardiac sodium channel<ref>PMID:19684871</ref>. | ||
| + | *'''beta-1-syntrophin''' is a scaffold protein that provides a platform for the formation of signal transduction complexes<ref>PMID:34277816</ref>. | ||
== Disease == | == Disease == | ||
| Line 14: | Line 16: | ||
Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>. | Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/3'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>. | ||
| - | </StructureSection> | ||
== 3D Structures of syntrophin == | == 3D Structures of syntrophin == | ||
| Line 20: | Line 21: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | * | + | *alpha-1-syntrophin |
**[[1z86]] – mSyn PDZ domain – mouse - NMR <br /> | **[[1z86]] – mSyn PDZ domain – mouse - NMR <br /> | ||
| Line 29: | Line 30: | ||
**[[2pdz]] – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR <br /> | **[[2pdz]] – mSyn PDZ domain + voltage-gated sodium channel peptide - NMR <br /> | ||
| - | * | + | *beta-1-syntrophin |
| + | |||
| + | **[[7pc4]] – hSyn PDZ domain 107-196 + TAX-1 peptide - human<br /> | ||
| + | **[[7p70]] – hSyn PDZ domain + HPV35-E6 peptide <br /> | ||
| + | |||
| + | *beta-2-syntrophin | ||
| + | |||
| + | **[[2vrf]] – hSyn PDZ domain <br /> | ||
| + | |||
| + | *gamma-1-syntrophin | ||
| + | |||
| + | **[[7qqn]] – hSyn PDZ domain 54-143 + TRPV3 peptide <br /> | ||
| + | **[[7pc7]] – hSyn PDZ domain + PTEN peptide <br /> | ||
| + | **[[7pc8]] – hSyn PDZ domain + RSK1 peptide <br /> | ||
| + | |||
| + | *gamma-2-syntrophin | ||
| + | |||
| + | **[[7qql]] – hSyn PDZ domain 70-159 + RSK1 peptide <br /> | ||
| - | **[[2vrf]] – Syn PDZ domain – human <br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
