6vo5
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4== | |
| + | <StructureSection load='6vo5' size='340' side='right'caption='[[6vo5]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6vo5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VO5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CO6:ISOBUTYRYL-COENZYME+A'>CO6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vo5 OCA], [https://pdbe.org/6vo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vo5 RCSB], [https://www.ebi.ac.uk/pdbsum/6vo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vo5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HAT1_HUMAN HAT1_HUMAN] Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.<ref>PMID:9427644</ref> <ref>PMID:11585814</ref> <ref>PMID:20953179</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone acetyltransferase 3D structures|Histone acetyltransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Dong | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Halabelian | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Dong A]] |
| - | [[Category: | + | [[Category: Edwards AM]] |
| + | [[Category: Halabelian L]] | ||
| + | [[Category: Loppnau P]] | ||
| + | [[Category: Zeng H]] | ||
Current revision
Crystal structure of Human histone acetytransferas 1 (HAT1) in complex with isobutryl-COA and K12A mutant variant of histone H4
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Dong A | Edwards AM | Halabelian L | Loppnau P | Zeng H
