6lry
From Proteopedia
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<StructureSection load='6lry' size='340' side='right'caption='[[6lry]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='6lry' size='340' side='right'caption='[[6lry]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6lry]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LRY OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6lry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atractaspis_engaddensis Atractaspis engaddensis], [https://en.wikipedia.org/wiki/Enterobacteria_phage_RB59 Enterobacteria phage RB59] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LRY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lry OCA], [https://pdbe.org/6lry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lry RCSB], [https://www.ebi.ac.uk/pdbsum/6lry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lry ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN]] Hirschsprung disease;Waardenburg-Shah syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Defects in EDNRB are associated with Waardenburg syndrome 2, with ocular albinism, autosomal recessive: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis.<ref>PMID:28236341</ref> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN]] Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:7536888</ref> [[http://www.uniprot.org/uniprot/SRTX_ATREN SRTX_ATREN]] Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.<ref>PMID:21889567</ref> Sarafotoxin-B: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).<ref>PMID:21889567</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atractaspis engaddensis]] | ||
| + | [[Category: Enterobacteria phage RB59]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Izume T]] | |
| - | [[Category: Izume | + | [[Category: Miyauchi H]] |
| - | [[Category: Miyauchi | + | [[Category: Nureki O]] |
| - | [[Category: Nureki | + | [[Category: Shihoya W]] |
| - | [[Category: Shihoya | + | |
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Current revision
Crystal structure of human endothelin ETB receptor in complex with sarafotoxin S6b
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