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6pt0

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==Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2==
==Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2==
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<StructureSection load='6pt0' size='340' side='right'caption='[[6pt0]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<SX load='6pt0' size='340' side='right' viewer='molstar' caption='[[6pt0]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6pt0]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PT0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6pt0]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PT0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=WI5:{(3R)-5-methyl-3-[(morpholin-4-yl)methyl]-2,3-dihydro[1,4]oxazino[2,3,4-hi]indol-6-yl}(naphthalen-1-yl)methanone'>WI5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pt0 OCA], [http://pdbe.org/6pt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pt0 RCSB], [http://www.ebi.ac.uk/pdbsum/6pt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pt0 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=WI5:[(11~{R})-2-methyl-11-(morpholin-4-ylmethyl)-9-oxa-1-azatricyclo[6.3.1.0^{4,12}]dodeca-2,4(12),5,7-tetraen-3-yl]-naphthalen-1-yl-methanone'>WI5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pt0 OCA], [https://pdbe.org/6pt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pt0 RCSB], [https://www.ebi.ac.uk/pdbsum/6pt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pt0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/CNR2_HUMAN CNR2_HUMAN]] Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.<ref>PMID:10051546</ref> <ref>PMID:12663043</ref> <ref>PMID:12711605</ref> <ref>PMID:18692962</ref> [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pt0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pt0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, M]]
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[[Category: Synthetic construct]]
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[[Category: Feng, Z]]
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[[Category: Chen M]]
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[[Category: Liu, H]]
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[[Category: Feng Z]]
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[[Category: McGuire, T]]
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[[Category: Liu H]]
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[[Category: Melcher, K]]
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[[Category: McGuire T]]
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[[Category: Meng, X]]
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[[Category: Melcher K]]
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[[Category: Wang, J]]
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[[Category: Meng X]]
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[[Category: Wang, L]]
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[[Category: Wang J]]
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[[Category: Xie, X Q]]
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[[Category: Wang L]]
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[[Category: Xing, C]]
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[[Category: Xie XQ]]
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[[Category: Xu, H E]]
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[[Category: Xing C]]
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[[Category: Xu, T H]]
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[[Category: Xu HE]]
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[[Category: Xue, Y]]
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[[Category: Xu TH]]
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[[Category: Zhang, C]]
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[[Category: Xue Y]]
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[[Category: Zhao, G]]
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[[Category: Zhang C]]
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[[Category: Zhou, X E]]
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[[Category: Zhao G]]
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[[Category: Zhuang, Y]]
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[[Category: Zhou XE]]
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[[Category: 212-2]]
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[[Category: Zhuang Y]]
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[[Category: Gpcr complex]]
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[[Category: Membrane protein]]
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[[Category: Win55]]
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Current revision

Cryo-EM structure of human cannabinoid receptor 2-Gi protein in complex with agonist WIN 55,212-2

6pt0, resolution 3.20Å

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