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6s8i

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==Structure of ZEBOV GP in complex with 3T0265 antibody==
==Structure of ZEBOV GP in complex with 3T0265 antibody==
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<StructureSection load='6s8i' size='340' side='right'caption='[[6s8i]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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<SX load='6s8i' size='340' side='right' viewer='molstar' caption='[[6s8i]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6s8i]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S8I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6s8i]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebov Ebov] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S8I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S8I FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8i OCA], [http://pdbe.org/6s8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8i RCSB], [http://www.ebi.ac.uk/pdbsum/6s8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8i ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GP, DF49_53415gpGP, DF49_53416gpGP, DF49_53417gpGP, DF49_53418gpGP, DF49_53419gpGP, DF49_53420gpGP, DF49_53421gpGP, DF49_53422gpGP, DF49_53423gpGP, DF49_53424gpGP, DF49_53425gpGP, DF49_53426gpGP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1570291 EBOV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s8i OCA], [http://pdbe.org/6s8i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s8i RCSB], [http://www.ebi.ac.uk/pdbsum/6s8i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s8i ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ebola virus disease is a severe health problem in Africa. Vaccines that display the Zaire ebolavirus glycoprotein spike complex are a prime component for the effort to combat it. The VH3-15/Vlambda1-40-based class of antibodies was recently discovered to be a common response in individuals who received the Ebola virus vaccines. These antibodies display attractive properties, and thus likely contribute to the efficacy of the vaccines. Here, we use cryo-EM to elucidate how three VH3-15/Vlambda1-40 antibodies from different individuals target the virus and found a convergent mechanism against a partially conserved site on the spike complex. Our study rationalizes the selection of the VH3-15/Vlambda1-40 germline genes for specifically targeting this site and highlights Ebolavirus species-specific sequence divergences that may restrict breadth of VH3-15/Vlambda1-40-based humoral response. The results from this study could help develop improved immunization schemes and further enable the design of immunogens that would be efficacious against a broader set of Ebolavirus species.
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Structural Basis for a Convergent Immune Response against Ebola Virus.,Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R Cell Host Microbe. 2020 Feb 6. pii: S1931-3128(20)30046-9. doi:, 10.1016/j.chom.2020.01.007. PMID:32059794<ref>PMID:32059794</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6s8i" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Ebov]]
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[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cohen-Dvashi, H]]
[[Category: Cohen-Dvashi, H]]

Current revision

Structure of ZEBOV GP in complex with 3T0265 antibody

6s8i, resolution 2.99Å

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