Thermolysin

[[Thermolysin]] (TML) is a thermostable metalloproteinase enzyme from ''Bacillus thermoproteolyticus''. It catalyzes the hydrolysis of peptide bonds containing hydrophobic residues. See [[Metalloproteases]] and [[Matrix metalloproteinase]] for discussion.

== 3D Structures of Thermolysin ==

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* Thermolysin

**[[2whz]], [[3fvp]], [[3dnz]], [[3do0]], [[3do1]], [[3do2]], [[2g4z]], [[2a7g]], [[1gxw]], [[1kei]], [[1l3f]], [[1tlx]], [[2tlx]], [[8tln]], [[3p7p]], [[3p7q]], [[3p7r]], [[3p7s]], [[3p7t]], [[3p7u]], [[3p7v]], [[3p7w]], [[3zi6]], [[5dlh]], [[5tli]], [[6tli]], [[7tli]], [[8tli]], [[5un3]], [[5uu7]], [[5wr2]], [[5wr3]], [[5wr4]], [[5wr5]], [[5wr6]], [[5a3y]], [[5o8n]], [[5uu8]], [[5uu9]], [[5uua]], [[5uub]], [[5uuc]], [[5uud]], [[5uue]], [[5fsj]], [[5fsp]], [[5fss]], [[5fxn]], [[5t9i]], [[5t9k]], [[5t9q]], [[5tac]], [[5tad]], [[5tae]], [[5tai]], [[5taj]], [[5tak]], [[5hqd]], [[6tli]], [[7tli]], [[8tli]], [[6d5o]], [[6fsm]], [[6d5p]], [[6d5q]], [[6d5r]], [[6d5s]], [[6d5t]], [[6d5u]], [[6fj2]] – TML<br />

**[[5dlh]] – TML - electron crystallography<br />

**[[3ls7]], [[4ow3]], [[4tnl]] - TML residues 233-548<br />

**[[1trl]] - TML residues 255-316 – NMR<br />

**[[3fxs]], [[3fbo]], [[3eim]], [[1lna]], [[1lnb]], [[1lnc]], [[1lnd]], [[1lne]], [[1lnf]] - TML residues 233-548+metal ion replacing Ca<br />

*Thermolysin TML+transition state analog

**[[1tlp]], [[1tmn]], [[2tmn]], [[4tmn]], [[5tmn]] – TML+transition state analog<br />

*Thermolysin + amino acid

**[[1kl6]] – TML residues 1-316 + alanine<br />

**[[4m65]] – TML residues 1-316 + asparagine<br />

**[[8tln]] – TML+ avaline + lysine<br />

**[[3qgo]] – TML + phenylalanine methyl ester<br />

**[[3qh1]] – TML + benzyloxycarboxyl- aspartate<br />

**[[3qh5]] – TML + benzyloxycarboxyl- aspartate + phenylalanine methyl ester

*Thermolysin + polypeptide

**[[2wi0]], [[3tmn]], [[8tln]] – TMLresidues 1-316 + dipeptide <br />

**[[3fgd]] - TML residues 233-548+dipeptide<br />

**[[5onp]], [[5onq]], [[5onr]], [[6ghx]] – TML residues 233-551 + amyloid-β peptide<br />

*Thermolysin + inhibitor

**[[1fjo]], [[1fj3]], [[1fjq]], [[1fjt]], [[1fju]], [[1fjv]], [[1fjw]], [[4tli]], [[5tli]], [[6tli]], [[7tli]], [[8tli]], [[1tli]], [[2tli]], [[3tli]] – TML residues 1-316 in organic solvents<br />

**[[3fv4]], [[3fxp]], [[3flf]], [[3fb0]], [[3fcq]], [[3f28]], [[3f2p]], [[4mtw]], [[4mwp]], [[4mxj]], [[4mzn]], [[4n4e]], [[4n5p]], [[4n66]], [[4oi5]], [[3for]], [[1y3g]], [[1zdp]], [[1z9g]], [[1os0]], [[1thl]], [[3ms3]], [[3msa]], [[3msf]], [[3msn]], [[3n21]], [[3nn7]], [[3t73]], [[3t74]], [[3t8]], [[3t8c]], [[3t8d]], [[3t8f]], [[3t8g]], [[3t8h]], [[4h57]], [[4d9w]], [[4d91]] – TML residues 233-548+inhibitor

**[[1pe5]], [[6tmn]], [[7tln]], [[4tln]], [[5tln]], [[1hyt]], [[1qf0]], [[1qf1]], [[1qf2]], [[1kjp]], [[1kjo]], [[1kto]], [[1ks7]], [[1kro]], [[1kr6]], [[1kkk]], [[pe7]], [[1pe8]] – TML residues 1-316 + inhibitor <br />

**[[3ssb]] – TML residues 233-548 + Impi-α<br />

**[[3t2h]] – TML residues 233-548 + trimethylamine oxide<br />

**[[3t2i]] – TML residues 233-548 + sarcosine<br />

**[[3t2j]] – TML residues 233-548 + betaine<br />

**[[6fhp]] – TML C terminal 490-551 + DAIP<br />

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