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5qxi

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(New page: '''Unreleased structure''' The entry 5qxi is ON HOLD Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F. Descri...)
Current revision (11:28, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5qxi is ON HOLD
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==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with PC587==
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<StructureSection load='5qxi' size='340' side='right'caption='[[5qxi]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5qxi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QXI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGY:(4R,4aS,7aS,9S)-3,10-dimethyl-5,6,7,7a,8,9-hexahydro-4H-4a,9-epiminopyrrolo[3,4 5,6]cyclohepta[1,2-d][1,2]oxazol-4-ol'>RGY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQS:(4R,4aR,7aS,9R)-3,10-dimethyl-5,6,7,7a,8,9-hexahydro-4H-4a,9-epiminopyrrolo[3,4 5,6]cyclohepta[1,2-d][1,2]oxazol-4-ol'>TQS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxi OCA], [https://pdbe.org/5qxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qxi RCSB], [https://www.ebi.ac.uk/pdbsum/5qxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref>
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Authors: Snee, M., Talon, R., Fowley, D., Collins, P., Nelson, A., Arrowsmith, C.H., Bountra, C., Edwards, A., Von-Delft, F.
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==See Also==
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*[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]]
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Description: PanDDA analysis group deposition --Crystal Structure of ATAD2 in complex with PC587
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Edwards, A]]
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__TOC__
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[[Category: Collins, P]]
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</StructureSection>
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[[Category: Snee, M]]
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[[Category: Homo sapiens]]
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[[Category: Bountra, C]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Arrowsmith CH]]
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[[Category: Nelson, A]]
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[[Category: Bountra C]]
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[[Category: Fowley, D]]
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[[Category: Collins P]]
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[[Category: Talon, R]]
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[[Category: Edwards A]]
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[[Category: Von-Delft, F]]
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[[Category: Fowley D]]
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[[Category: Nelson A]]
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[[Category: Snee M]]
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[[Category: Talon R]]
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[[Category: Von-Delft F]]

Current revision

PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with PC587

PDB ID 5qxi

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