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5qxo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF848== | |
| + | <StructureSection load='5qxo' size='340' side='right'caption='[[5qxo]], [[Resolution|resolution]] 1.47Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5qxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QXO FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RH7:methyl+(5aS,8aS,10S)-8,8a,9,10-tetrahydro-5H-5a,10-epoxypyrrolo[3,4 4,5]cyclohepta[1,2-b]pyrazine-7(6H)-carboxylate'>RH7</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qxo OCA], [https://pdbe.org/5qxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qxo RCSB], [https://www.ebi.ac.uk/pdbsum/5qxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qxo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ATAD2_HUMAN ATAD2_HUMAN] May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.<ref>PMID:17998543</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[ATPase family AAA domain-containing protein|ATPase family AAA domain-containing protein]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Nelson | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Collins P]] |
| - | [[Category: Talon | + | [[Category: Edwards A]] |
| - | [[Category: Von-Delft | + | [[Category: Fowley D]] |
| + | [[Category: Nelson A]] | ||
| + | [[Category: Snee M]] | ||
| + | [[Category: Talon R]] | ||
| + | [[Category: Von-Delft F]] | ||
Current revision
PanDDA analysis group deposition -- Crystal Structure of ATAD2 in complex with DF848
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Collins P | Edwards A | Fowley D | Nelson A | Snee M | Talon R | Von-Delft F
