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6lxe

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(New page: '''Unreleased structure''' The entry 6lxe is ON HOLD Authors: Jin, W., Wang, J., Liu, C.P., Wang, H.W., Xu, R.M. Description: DROSHA-DGCR8 complex Category: Unreleased Structures [...)
Current revision (10:47, 27 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6lxe is ON HOLD
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==DROSHA-DGCR8 complex==
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<StructureSection load='6lxe' size='340' side='right'caption='[[6lxe]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
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Authors: Jin, W., Wang, J., Liu, C.P., Wang, H.W., Xu, R.M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6lxe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXE FirstGlance]. <br>
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Description: DROSHA-DGCR8 complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Xu, R.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxe OCA], [https://pdbe.org/6lxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxe RCSB], [https://www.ebi.ac.uk/pdbsum/6lxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxe ProSAT]</span></td></tr>
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[[Category: Wang, H.W]]
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</table>
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[[Category: Liu, C.P]]
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== Function ==
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[[Category: Wang, J]]
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[https://www.uniprot.org/uniprot/RNC_HUMAN RNC_HUMAN] Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.<ref>PMID:10948199</ref> <ref>PMID:14508493</ref> <ref>PMID:15589161</ref> <ref>PMID:15574589</ref> <ref>PMID:15531877</ref> <ref>PMID:15565168</ref> <ref>PMID:16751099</ref> <ref>PMID:16906129</ref> <ref>PMID:17159994</ref>
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[[Category: Jin, W]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jin W]]
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[[Category: Liu CP]]
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[[Category: Wang HW]]
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[[Category: Wang J]]
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[[Category: Xu RM]]

Current revision

DROSHA-DGCR8 complex

PDB ID 6lxe

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