6lxw
From Proteopedia
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(New page: '''Unreleased structure''' The entry 6lxw is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA== | |
| + | <StructureSection load='6lxw' size='340' side='right'caption='[[6lxw]], [[Resolution|resolution]] 3.27Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxw OCA], [https://pdbe.org/6lxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxw RCSB], [https://www.ebi.ac.uk/pdbsum/6lxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and pIgR/SC facilitate the assembly and secretion of SIgA remains incompletely understood. Furthermore, during the infection of Streptococcus pneumoniae, the pneumococcal adhesin SpsA hijacks pIgR/SC and SIgA to gain entry to human cells and evade host defense. How SpsA targets pIgR/SC and SIgA also remains elusive. Here we report a cryo-electron microscopy structure of the Fc region of IgA1 (Fcalpha) in complex with the J-chain and SC (Fcalpha-J-SC), which reveals the organization principle of SIgA. We also present a structure of Fcalpha-J-SC complexed with SpsA, which uncovers the specific interactions between SpsA and human pIgR/SC. These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis. | ||
| - | + | Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.,Wang Y, Wang G, Li Y, Zhu Q, Shen H, Gao N, Xiao J Cell Res. 2020 May 12. pii: 10.1038/s41422-020-0336-3. doi:, 10.1038/s41422-020-0336-3. PMID:32398862<ref>PMID:32398862</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6lxw" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Wang G]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Xiao J]] | ||
Current revision
Cryo-EM structure of human secretory immunoglobulin A in complex with the N-terminal domain of SpsA
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Categories: Large Structures | Li Y | Wang G | Wang Y | Xiao J
