6y1e

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'''Unreleased structure'''
 
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The entry 6y1e is ON HOLD until sometime in the future
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==Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)==
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<StructureSection load='6y1e' size='340' side='right'caption='[[6y1e]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6y1e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y1E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.402&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=O7Z:2-[[6,7-bis(chloranyl)-2-cyclopentyl-2-methyl-1-oxidanylidene-3~{H}-inden-5-yl]oxy]ethanoic+acid'>O7Z</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1e OCA], [https://pdbe.org/6y1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y1e RCSB], [https://www.ebi.ac.uk/pdbsum/6y1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
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Authors: Pandian, R., Worth, R., Thangaraj, V., Sayed, Y., Dirr, H.W.
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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Description: Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Dirr, H.W]]
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__TOC__
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[[Category: Pandian, R]]
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</StructureSection>
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[[Category: Thangaraj, V]]
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[[Category: Homo sapiens]]
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[[Category: Sayed, Y]]
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[[Category: Large Structures]]
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[[Category: Worth, R]]
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[[Category: Dirr HW]]
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[[Category: Pandian R]]
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[[Category: Sayed Y]]
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[[Category: Thangaraj V]]
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[[Category: Worth R]]

Current revision

Crystal structure of human glutathione transferase P1-1 (hGSTP1-1) that was co-crystallised in the presence of indanyloxyacetic acid-94 (IAA-94)

PDB ID 6y1e

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OCA

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