6ue9

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==Structure of tetrameric sIgA complex (Class 2)==
==Structure of tetrameric sIgA complex (Class 2)==
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<StructureSection load='6ue9' size='340' side='right'caption='[[6ue9]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<SX load='6ue9' size='340' side='right' viewer='molstar' caption='[[6ue9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6ue9]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UE9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ue9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UE9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ue9 OCA], [http://pdbe.org/6ue9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ue9 RCSB], [http://www.ebi.ac.uk/pdbsum/6ue9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ue9 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ue9 OCA], [https://pdbe.org/6ue9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ue9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ue9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ue9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IGHA2_HUMAN IGHA2_HUMAN]] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. [[http://www.uniprot.org/uniprot/IGJ_HUMAN IGJ_HUMAN]] Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.[UniProtKB:P01592] [[http://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN]] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
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[https://www.uniprot.org/uniprot/IGHA2_HUMAN IGHA2_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arthur, C P]]
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[[Category: Arthur CP]]
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[[Category: Ciferri, C]]
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[[Category: Ciferri C]]
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[[Category: Kumar, N]]
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[[Category: Kumar N]]
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[[Category: Matsumoto, M L]]
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[[Category: Matsumoto ML]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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Current revision

Structure of tetrameric sIgA complex (Class 2)

6ue9, resolution 2.90Å

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