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6xvd

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<StructureSection load='6xvd' size='340' side='right'caption='[[6xvd]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='6xvd' size='340' side='right'caption='[[6xvd]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6xvd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XVD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6XVD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xvd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XVD FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xvd OCA], [http://pdbe.org/6xvd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xvd RCSB], [http://www.ebi.ac.uk/pdbsum/6xvd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xvd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xvd OCA], [https://pdbe.org/6xvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xvd RCSB], [https://www.ebi.ac.uk/pdbsum/6xvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xvd ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[http://omim.org/entry/601709 601709]]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN]] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6xvd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6xvd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Synthetic construct]]
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[[Category: Huang, M D]]
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[[Category: Huang MD]]
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[[Category: Jiang, L G]]
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[[Category: Jiang LG]]
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[[Category: Xie, X]]
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[[Category: Xie X]]
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[[Category: Xue, G P]]
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[[Category: Xue GP]]
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[[Category: Yuan, C]]
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[[Category: Yuan C]]
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[[Category: Zhou, Y]]
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[[Category: Zhou Y]]
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[[Category: Cyclic peptide inhibitor]]
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[[Category: Peptide binding protein]]
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[[Category: Upain-1-w3f]]
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[[Category: Urokinase]]
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Current revision

Crystal structure of complex of urokinase and a upain-1 variant(W3F) in pH7.4 condition

PDB ID 6xvd

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