2jr5

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==Solution structure of UPF0350 protein VC_2471. Northeast Structural Genomics Target VcR36==
==Solution structure of UPF0350 protein VC_2471. Northeast Structural Genomics Target VcR36==
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<StructureSection load='2jr5' size='340' side='right'caption='[[2jr5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2jr5' size='340' side='right'caption='[[2jr5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jr5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JR5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JR5 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VC_2471 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr5 OCA], [http://pdbe.org/2jr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jr5 RCSB], [http://www.ebi.ac.uk/pdbsum/2jr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jr5 OCA], [https://pdbe.org/2jr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jr5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jr5 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SDHE_VIBCH SDHE_VIBCH] An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.[UniProtKB:G4V4G2]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jr5 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jr5 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
 
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== Publication Abstract from PubMed ==
 
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The yeast mitochondrial protein Sdh5 is required for the covalent attachment of flavin adenine dinucleotide (FAD) to protein Sdh1, a subunit of the heterotetrameric enzyme succinate dehydrogenase. The NMR structure of Sdh5 represents the first eukaryotic structure of Pfam family PF03937 and reveals a conserved surface region, which likely represents a putative Sdh1-Sdh5 interaction interface. Point mutations in this region result in the loss of covalent flavinylation of Sdh1. Moreover, chemical shift perturbation measurements showed that Sdh5 does not bind FAD in vitro, indicating that it is not a simple cofactor transporter in vivo.
 
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Solution NMR Structure of Yeast Succinate Dehydrogenase Flavinylation Factor Sdh5 Reveals a Putative Sdh1 Binding Site.,Eletsky A, Jeong MY, Kim H, Lee HW, Xiao R, Pagliarini DJ, Prestegard JH, Winge DR, Montelione GT, Szyperski T Biochemistry. 2012 Oct 19. PMID:23062074<ref>PMID:23062074</ref>
 
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
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</div>
 
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<div class="pdbe-citations 2jr5" style="background-color:#fffaf0;"></div>
 
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillo virgola del koch trevisan 1884]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Acton, T B]]
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[[Category: Vibrio cholerae]]
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[[Category: Baran, M C]]
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[[Category: Acton TB]]
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[[Category: Eletski, A]]
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[[Category: Baran MC]]
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[[Category: Liu, J]]
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[[Category: Eletski A]]
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[[Category: Maglaqui, M]]
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[[Category: Liu J]]
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[[Category: Montelione, G T]]
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[[Category: Maglaqui M]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Nwosu, C]]
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[[Category: Nwosu C]]
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[[Category: Parish, D]]
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[[Category: Parish D]]
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[[Category: Rost, B]]
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[[Category: Rost B]]
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[[Category: Shastry, R]]
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[[Category: Shastry R]]
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[[Category: Singarapu, K K]]
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[[Category: Singarapu KK]]
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[[Category: Sukumaran, D]]
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[[Category: Sukumaran D]]
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[[Category: Swapna, G]]
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[[Category: Swapna G]]
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[[Category: Szyperski, T]]
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[[Category: Szyperski T]]
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[[Category: Wu, Y]]
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[[Category: Wu Y]]
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[[Category: Xiao, R]]
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[[Category: Xiao R]]
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[[Category: Nesg]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Unknown function]]
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[[Category: Upf0350 protein vc_2471]]
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Current revision

Solution structure of UPF0350 protein VC_2471. Northeast Structural Genomics Target VcR36

PDB ID 2jr5

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