5do2

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<StructureSection load='5do2' size='340' side='right'caption='[[5do2]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
<StructureSection load='5do2' size='340' side='right'caption='[[5do2]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5do2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DO2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5do2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Middle_East_respiratory_syndrome-related_coronavirus Middle East respiratory syndrome-related coronavirus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DO2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.409&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kr0|4kr0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5do2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do2 OCA], [http://pdbe.org/5do2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5do2 RCSB], [http://www.ebi.ac.uk/pdbsum/5do2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5do2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5do2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5do2 OCA], [https://pdbe.org/5do2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5do2 RCSB], [https://www.ebi.ac.uk/pdbsum/5do2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5do2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/K0BRG7_MERS K0BRG7_MERS] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099] Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099] Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5do2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5do2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Sandbox 3001|Sandbox 3001]]
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*[[Spike protein 3D structures|Spike protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mers]]
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[[Category: Middle East respiratory syndrome-related coronavirus]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Gao, G F]]
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[[Category: Gao GF]]
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[[Category: Li, Y]]
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[[Category: Li Y]]
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[[Category: Liu, P]]
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[[Category: Liu P]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Lu, G]]
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[[Category: Lu G]]
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[[Category: Lu, X]]
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[[Category: Lu X]]
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[[Category: Perlman, S]]
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[[Category: Perlman S]]
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[[Category: Qi, J]]
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[[Category: Qi J]]
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[[Category: Wan, Y]]
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[[Category: Wan Y]]
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[[Category: Wang, Q]]
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[[Category: Wang Q]]
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[[Category: Wu, Y]]
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[[Category: Wu Y]]
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[[Category: Yan, J]]
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[[Category: Yan J]]
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[[Category: Yuen, K Y]]
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[[Category: Yuen KY]]
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[[Category: Zhao, J]]
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[[Category: Zhao J]]
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[[Category: 4c2 antibody]]
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[[Category: Neuralization]]
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[[Category: Receptor-binding blocking]]
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[[Category: Receptor-binding domain of mers-cov spike]]
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[[Category: Viral protein-immune system complex]]
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Current revision

Complex structure of MERS-RBD bound with 4C2 antibody

PDB ID 5do2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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