5ea9

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Current revision (06:19, 5 July 2023) (edit) (undo)
 
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<StructureSection load='5ea9' size='340' side='right'caption='[[5ea9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
<StructureSection load='5ea9' size='340' side='right'caption='[[5ea9]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ea9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EA9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EA9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ea9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EA9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5LM:5-[(E)-3-THIOPHEN-2-YLPROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5e93|5e93]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5LM:5-[(E)-3-THIOPHEN-2-YLPROP-2-ENYLIDENE]-1,3-DIAZINANE-2,4,6-TRIONE'>5LM</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PyrD,pyr4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ea9 OCA], [https://pdbe.org/5ea9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ea9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ea9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ea9 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ea9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ea9 OCA], [http://pdbe.org/5ea9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ea9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ea9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ea9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
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[https://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycc]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Cheleski, J]]
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[[Category: Cheleski J]]
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[[Category: Harada, S]]
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[[Category: Harada S]]
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[[Category: Inaoka, D K]]
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[[Category: Inaoka DK]]
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[[Category: Kita, K]]
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[[Category: Kita K]]
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[[Category: Montanari, C A]]
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[[Category: Montanari CA]]
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[[Category: Rocha, J R]]
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[[Category: Rocha JR]]
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[[Category: Shiba, T]]
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[[Category: Shiba T]]
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[[Category: Covalent inhibitor]]
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[[Category: Dihydroorotate dehydrogenase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: T. cruzi]]
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Current revision

Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130

PDB ID 5ea9

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